Background: Pentraxin-3 (PTX-3) (an acute-phase protein) is a member of the long pentraxin protein family. It has been reported that PTX-3 is significantly associated with obesity, metabolic syndrome and cardiovascular diseases. Objective: To study plasma Pentraxin-3 levels in nonalcoholic fatty liver disease (NAFLD) among Egyptian patients. Patients and Methods: Fifty Egyptian patients divided into three groups: Group I: 20 non-alcoholic fatty liver disease (NAFLD) patients with Simple Steatosis (non-NASH), Group II: 20 NAFLD patients with Steatohepatitis (NASH), and Group III: 10 healthy subjects as controls (age and sex matched). Results: Pentraxin-3 was found significantly higher in NASH group than non-NASH group, and also significantly higher in non-NASH group than control group. It was 5.65 (4.1 – 7.15) in NASH, 1.7 (0.85 – 2.5) in non-NASH and 0.85 (0.6 – 1.1) in control group. Conclusion: Patients with NASH showed increased level of pentrxin-3.