Background: The cryoprobe is a closed system that can be re-sterilized and reused. It is well established as a safe procedure in taking endobronchial biopsies. Recent reports have risen as an alternative of the traditional forceps methods. Objective: To assess the diagnostic yield and safety of cryoprobe in patients with endobronchial neoplasms. Patients and Methods: Thirty patients who underwent bronchoscopy were included in this study at Chest diseases Departments (Endoscopic Unit) of Al -Azhar University Hospitals from August 2018 to August 2020 hospital. Endobronchial biopsies were taken by forceps biopsy and cryobiopsy with ERBE cryo probe from each subject. Results: Twenty-five patients (83.33%) were diagnosed using cryoprobe biopsy, while 18 patients (60%) were diagnosed with forceps biopsy (P<0.05). Bleeding was the recorded complication in both procedures with no significant difference between them in the incidence of bleeding. Conclusion: Cryoprobe biopsies were more successful than forceps biopsies in the diagnosis of lung cancer.