Background: Septoplasty or septal reconstruction is a corrective surgical procedure performed to straighten nasal septum. It may be associated with numerous complications. To minimize these complications, both nasal cavities are frequently packed with different types of nasal packing. The solid and porous characteristics of Merocel not only help in better hemostasis, but also cause more pain during insertion of nasal pack, pain while pack is inside the nasal cavity, and pain during removal of the pack. Objective: To investigate the effect of using Merocel in glove finger over plain Merocel as a nasal packing after septoplasty. Patients and methods: Data for this study was collected from patients attending in Al-Sahel teaching hospital during period from March 2019 to December 2020. In this study, the total number of patients is 60, the age ranged from 18 to 45 (38 males, 22 females). All patients presented with symptomatic deviated nasal septum. All cases are diagnosed after taking a detailed history regarding nasal obstruction and associated symptoms like nasal discharge and headache and by endoscopic examination to detect the site of deviation and other nasal abnormalities. Results: In this study the range of pain scoring in group A was (1-6) and the mean ±SD was 3.300 ± 1.291 while the range in group B was (3-9) and the mean ± SD was 6700 ± 1.489. In this study, moderate bleeding was observed in one patient (3.33%) during pack removal in Group A. In Group B, 18 patients (60%) had moderate bleeding on pack removal, suggesting that glove finger‑coated Merocel plays a role in avoiding friction between Merocel and surgical wound on pack removal, which reduces mucosal damage or bleeding amount. In this study, mild postoperative crustation was observed in 10 patients (33.33%) after pack removal n group A, while in group B there were 14 patients (46.67%). There were no patients with moderate postoperative crustation n group A, while in group B there were 10 patients (33.33%). Conclusion: Gloved Merocel produces less pain and bleeding during its removal and less postoperative crustation, adhesion and inflammation. Gloved Merocel is preferred over ungloved Merocel as nasal packing following septoplasty. Thus, glove finger Merocel can be used as an excellent packing material.