Background: Preterm labor (PTL) and delivery remain a significant problem in contemporary obstetric practice. Although the exact cause remains unclear, it is most likely to be multifactorial in nature. Progesterone may be effective in prevention of premature birth in some high risk populations. Women with arrested premature labor are at risk of recurrent labor and maintenance therapy with standard tocolytics has not been successful. Objective: To compare the efficacy and safety of beta-sympathomimetics (Ritodrine) and Progesterone for maintenance tocolysis after arrested preterm labor for prolongation of pregnancy and prevention of recurrence of preterm labor. Subjects and methods: This study was a case-control study which was carried out to evaluate the efficacy and safety of beta-sympathomimetics (Ritodrine) and Progesterone for maintenance tocolysis after arrested preterm labor. This study was carried out on 100 pregnant women attending Sohag Teaching Hospital and Al-Azhar University Hospital (Al-Hussein) in gestational age between 28 and 37 weeks, from August 2019 to August 2020. Patients were divided into two equal groups: Group (A) received oral ritodrine (yutopar), and Group (B) received progesterone vaginal suppository (prontogest 400). Results: Among participants in Group A, there were 41 (82%) multigravida and 9 (18%) primigravida, while in Group B there were 45 (90%) multigravida and 5 (10%) primigravida. The mean maternal age in Group A was 25.52 (±3.94 SD) with range (19-32), while the mean maternal age in Group B was 26.64 (±3.84 SD) with range (21-32). There were 27 (54%) in Group A who had Previous PTL or abortion while there were 21 (42%) in Group B only. There was a high statistically significant difference between the studied groups as regard outcome babies. Conclusion: Progesterone has the upper hand on ritodrine in maintenance tocolysis. Also, it showed that neonatal outcomes were better with progesterone and the maternal side effects were fewer with progesterone than ritodrine.