Background: Fetal growth disorders are an important cause of perinatal morbidity and mortality. The accurate assessment of fetal growth during pregnancy is difficult, but recent advances have improved this important aspect of obstetric care with positive implications for antenatal patients and their babies. Intrauterine growth restriction (IUGR) is the pathological counterpart of small-for-gestational age (SGA). So IUGR is a condition with an increased risk of a pathological condition that adversely affects the inherent potential growth of the fetus. Objective: To determine the correlation between anti cardiolipine & protein C & protein S and umbilical & middle cerebral artery blood flow in intrauterine growth restriction fetus. Patients and Methods: This study is prospective observational study, was conducted on 130 pregnant women presented to us at (Al-Azhar university Hospitals) (Al-Hussin),from 1/1/2017 to 1/1/2019, where 100 of them were diagnosed with intra uterine growth restriction fetuses at (28-32 weeks, study group) and recruited from the obstetric outpatient clinic and department and 30 women with normal pregnancy were also recruited as (control group) also at (28-32 weeks) from those who coming for routine antenatal care. Results: Majority of the patients forming our study were in the age group of 20 to 30 years and most of them were Primigravida. Associated risk factors were Hypertension disorders with pregnancy (PIH&PET), diabetes mellitus and anemia, PIH was the most common risk factor. Pathologically Growth restricted Fetuses showed abnormal Trends in the Doppler indices elevated indices in umbilical artery and low indices in middle cerebral artery (MCA) and there is a significant correlation with positive thrombophilia (anticardiolipin, & protein S), but not significant correlation with protein C. Conclusion: The value and accuracy of the Doppler indices (S/D,RI&PI) of the umbilical & middle cerebral arteries and its correlation with some thrombophilia markers (anticardiolipin, protein C & protein S) in the IUGR, is a better index for predicting adverse outcomes in IUGR when compared with control group.