Background: The harmful effect of a phenolic type of environmental toxicant, known as bisphenol A (BPA), has achieved great relevance. The interest in this compound is increasing owing to its possible adverse effects on several organs, which has led several organizations to recommend the prohibition or at least use reduction. BPA has also aroused interest in the nephrological community, as it has been linked to kidney and endocrine disorders. Since BPA is cleared by the kidneys, plasma and tissue levels of BPA are markedly increased in patients with impaired renal function.
Objective: The present work was designed to Study Histopathological and histochemical changes caused by Bisphenol A in the kidney and testis of albino rats and to identify the potential protective role of vitamin C on Bisphenol A toxicity.
Materials and Methods: One hundred (100) adult healthy male albino rats Weigh ting 180 – 220 gm were obtained from the animal house, Faculty of Medicine, Assiut University, Egypt and housed in a clean capacious macro-lane cages (5 per cage) under standard laboratory conditions including good aerated room with suitable temperature, relative humidity, maintained at good light with alternating 12 hours light/dark cycles. All rats were given normal rat diet during the experimental period with free access to water.
Results: Bisphenol A has deleterious effects on the histological structure of the testis and kidney of albino rats. Testis and kidney of rat administrated vitamin C in combination with Bisphenol A showed marked amelioration of the degenerative changes that were observed in rats administrated Bisphenol A alone. Effects of Bisphenol A on Testis and kidney of rat after recovery for two weeks were still as in group II while other effects worse. The only effects which disappear were hemorrhage and inflammatory infiltrate.
Conclusion: BPA has many toxic adverse health effects including reproductive and renal toxicity.