Background: Left atrial (LA) speckle tracking echocardiography (STE) is a newer echocardiographic technique for strain and strain rate analyses that tracks ‘speckles' or natural acoustic markers in the two-dimensional (2D) ultrasound image. STE has been described for assessment of regional and global LA function. Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that is characterized by inflammation and damage to multiple organ systems. Cardiac involvement can be seen in over 50% of lupus patients. Objective: To evaluate LA function and volume by STE-derived strain and strain rate in SLE patients compared to controls and assess the relationship of LA function and varying grades of Left ventricular diastolic dysfunction (LVDD) in SLE patients. Patients and Methods: Sixty SLE patients aged 20 to 40 with normal LV systolic function (LVEF > 50%).  SLE patients met the 2012 ACR revised criteria for SLE, were enrolled in this study. Age and sex matched apparently healthy forty subjects were included in this study as controls. Both of patients and control groups were selected from the attendants of Rheumatology Department and Cardiology Department of Al-Azhar University hospitals. Results: No statistically significant difference between patients and control groups as regarding age, gender, body surface area (BSA), systolic blood pressure (SBP) and Diastolic blood pressure (DBP). The Left atrial volume index (LAVI) was significantly larger in the SLE patients group than that in control group. Diastolic function was normal in 31.66%, impaired relaxation in 26.7%, pseudo normal in 38.33% and restrictive in 3.34%. Global strain, derived as an average of all segments, was 25.80±6.33 in SLE group vs. 33.12±8.71 in control group. Septal, lateral and apical longitudinal strains reduced in SLE patients with significantly differences between both groups.LA SRa increased in SLE group compared with that in control group (1.97±0.47 vs 1.57±0.60). There were significant differences in LAVI, SRs, SRe and SRa among normal and abnormal diastolic function in patients of the SLE group. The correlation between LVDD and left atrial SRs, SRe and, SRa showed that there were significant correlations with SRs, SRe but not significant with SRa. Conclusion: LA function impaired in SLE patients. Left atrial remodeling and impaired LA mechanical functions can be detected accurately with speckle tracking echocardiography. Assessment of LA strain represents a simple, accurate and reproducible technique to evaluate LA function.