Background: Strategic multidisciplinary protocols for enhanced recovery after surgery (ERAS) have demonstrated reductions in length of hospital stay (LOS), morbidity, and costs in conjunction with bariatric procedures, Although enhanced recovery after surgery has made great progress in the field of surgery, the guidelines point to the lack of high-quality evidence in upper gastrointestinal surgery. Objectives: To evaluate the outcomes of ERAS program in sleeve gastrectomy. Patients and methods: This was a randomized clinical trial that was carried out at Al-Hussein Hospital, Al-Azhar University. The study was conducted on 50 patients. All patients underwent sleeve gastrectomy during the study period. The patients in the group A received conventional perioperative care plan, and ERAS perioperative care plan was given to the patients in the group B. Results: There was a significant difference between the two studied groups regarding complications which were more frequent in group A. There was a significant difference between the two studied groups regarding early oral intake, drain from components compliance, and  overall compliance. Conclusion: The enhanced recovery after surgery protocol in the setting of bariatric surgery shortened hospital stay and was cost-effective. There was no increase in perioperative morbidity. Enhanced recovery after surgery was safe, effective in laparoscopic bariatric surgery, and can be further clinically popularized.