Background: Intraoperative cholangiography (IOC) is one of the surgical advances that aim to evaluate the billary system and reduce the risk of laparoscopic cholecystectomy (LC) complications. Objective: To evaluate the Common bile duct (CBD) preoperatively in gallstone patients using ultrasound alone versus added laparoscopic cholangiography during cholecystectomy. Patients and Methods: This prospective randomized study at the Department of Surgery, Faculty of Medicine, Al-Azhar University from November 2019 till September 2020 ,were 40 patients randomized divided into two equal  groups: Group I received laparoscopic cholecystectomy and Group II received laparoscopic cholecystectomy with intra operative trans-cystic cholangiography. Adult patients with good general condition were enrolled if they were diagnosed with symptomatic gall stones. Our protocol was approved by the institutional review board at Faculty of Medicine, Al-Azhar University and all participants signed an informed written consent before the procedure. Results: IOC scored the highest visualization rate, sensitivity and specificity rate (100%). Success rate was also high reaching 95%. Conclusion: IOC during LC was associated with a low morbidity rate and no mortalities. This confirmed the effectiveness of IOC in reducing the postoperative complications of LC.