Background: Liver is the main source of Butyrylcholinesterase (serum cholinesterase). It is a non-specific cholinesterase that is reduced in patients with advanced liver diseases. Measurement of serum Butyrylcholinesterase activity serves as a sensitive indicator of synthetic capacity of the liver.
Objective: To evaluate serum cholinesterase levels in chronic liver disease patients.
Patients and methods: In this study serum cholinesterase level was evaluated in chronic liver disease patients by a colorimetric kinetic assay method. Thirty cirrhotic subjects and thirty non-cirrhotic hepatic disease subjects were compared to 20 normal individuals. This study was done at Al-Azhar University Hospitals in the period between June 2018 and August 2020.
Results:  A significant decrease in serum Cholinestrease level was observed in all patients of chronic liver disease as compared to control group.
Conclusion: Serum cholinesterase is a better diagnostic and prognostic marker than the conventional liver function test that are raised in other liver disease also.