Background: Microparticles are small vesicles, between 0.1 and 1 μm in diameter. There are found in low concentrations in the plasma under physiological conditions and increased in pathological conditions. Objective: To find the correlation between circulating microparticles levels and thrombotic burden in acute myocardial infarction. Patients and methods: The study was conducted on 86 patients presented with acute myocardial infarction with ST-elevation, to the emergency Department at Ahmed Maher Teaching Hospital from September 1st 2019 till February 28th 2020. They were compared with 14 healthy individuals with identical demographic characteristics not suffering from any disease. Serum microparticles (CD41a) & (CD62E) and serum CKMB, troponin I, AST, and creatinine levels were measured in both groups. Results: There were  significant elevation of all parameters cardiac marker, CD41, and CD62E levels were observed in all patients of STEMI patients compared to the control group (p=<0.001). Conclusion: In STEMI patients, the serum CD41a and CD62E levels rise due to their property as proinflammatory and thrombtic CD41 & CD62E can be used as a predictor of STEMI.