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158633

CLINICAL COMPARATIVE STUDY BETWEEN INTRATHECAL DEXMEDETOMIDINE AND DEXAMETHASONE ON PROLONGING THE DURATION OF INTRATHECAL BLOCKADE IN LOWER LIMB ORTHOPEDIC SURGERY

Article

Last updated: 04 Jan 2025

Subjects

-

Tags

Medicine

Abstract

Background: Spinal anesthesia is safer than general anesthesia during lower limb operations; many studies have been concerned about prolonging the duration of spinal anesthesia by adding different adjuvants.
Objective: To compare the efficacy of intrathecal dexmedetomidine versus intrathecal dexamethasone in prolonging duration of spinal anesthesia, and postoperative analgesia, safety and hemodynamic stability.
Patients and methods: Our study was carried out on 60 patients of American Society of Anesthesiologists (ASA) physical status I or II, scheduled for orthopedic operation under spinal anesthesiadivided into A, B and C from March 2020 to November 2020. They were divided into 3 equal groups: Group A received 2ml bupivacaine (0.5%) and 10μg dexmedetomidine in 1ml normal saline intrathecal, Group B received 2ml bupivacaine (0.5%) and 4 mg dexamethasone in 1 ml normal saline intrathecal and Group Creceived 2ml bupivacaine (o.5%) and 1ml normal saline Intrathecal. The study was carried out at Al-Azhar University Hospitals (Al- Hussein and Sayed Galal Hospitals).
Results: The present study showed statistically significant difference (P-value <0.001) between the three groups according to time of motor and sensory regression. The regression time of block (both sensory and motor) were prolonged in A (sensory 359.50±20.32, motor 319.00±21.06) and B (sensory 199.75±18.22, motor 170.00±20.00) when compared to the C group (sensory 149.55±10.83, motor 141.00±22.09). However, the duration was longest in A group among the three groups. According to amount of analgesic consumption postoperatively, there was significant decrease in amount in A group in comparison to B and C groups. The amount is insignificantly decreased in B group in comparison to C group. Regarding safety and hemodynamic stability there was no statistically significant difference between the three groups.
Conclusion: Dexmedetomidine had prolonging the duration of spinal anesthesia more than dexamethasone and control group with statistically significant difference between the three groups and provided prolonged postoperative analgesia compared to dexamethasone and control group.

DOI

10.21608/amj.2021.158633

Keywords

Intrathecal dexmedetomidine, intrathecal dexamethasone, Spinal anesthesia

Authors

First Name

Ahmed

Last Name

Abd El-Hamed Hassan

MiddleName

-

Affiliation

Department of Anesthesia and Intensive Care, Faculty of Medicine, Al-Azhar University

Email

ahmedabdelhamed@azhar.edu.eg

City

-

Orcid

-

First Name

Ali

Last Name

Abd-Allah Al-Kumity

MiddleName

-

Affiliation

Department of Anesthesia and Intensive Care, Faculty of Medicine, Al-Azhar University

Email

-

City

-

Orcid

-

First Name

Alaa

Last Name

El-Deen Mahmoud Sayed Ahmed

MiddleName

-

Affiliation

Department of Anesthesia and Intensive Care, Faculty of Medicine, Al-Azhar University

Email

-

City

-

Orcid

-

First Name

Ismaeil

Last Name

Abd El-Latif Shabaiek

MiddleName

-

Affiliation

Department of Anesthesia and Intensive Care, Faculty of Medicine, Al-Azhar University

Email

-

City

-

Orcid

-

Volume

50

Article Issue

2

Related Issue

23274

Issue Date

2021-04-01

Receive Date

2021-03-23

Publish Date

2021-04-01

Page Start

1,467

Page End

1,478

Print ISSN

1110-0400

Link

https://amj.journals.ekb.eg/article_158633.html

Detail API

https://amj.journals.ekb.eg/service?article_code=158633

Order

58

Type

Original Article

Type Code

941

Publication Type

Journal

Publication Title

Al-Azhar Medical Journal

Publication Link

https://amj.journals.ekb.eg/

MainTitle

CLINICAL COMPARATIVE STUDY BETWEEN INTRATHECAL DEXMEDETOMIDINE AND DEXAMETHASONE ON PROLONGING THE DURATION OF INTRATHECAL BLOCKADE IN LOWER LIMB ORTHOPEDIC SURGERY

Details

Type

Article

Created At

22 Jan 2023