Background: In women with severe PE, the use of magnesium sulfate (MgSO₄) is indicated for prevention and control of acute convulsions. Several randomized trials have compared the efficacy of MgSO₄ with other anticonvulsants in women with eclampsia, and the rates of recurrent seizures and maternal death significantly reduced with MgSO₄ as compared with other anticonvulsants.
Objective: To assess the effect of magnesium sulfate injection on Doppler indices and fetal circulation in cases of severe pre-eclampsia.
Patients And Methods: This was a prospective study that conducted on one hundred pregnant women suffering from pre-eclampsia, selected from the Obstetrics and Gynecology Department of Al-Hussein University Hospital from January 2018 to December 2018, evaluated before and after administration of magnesium sulfate, Doppler ultrasound was carried out to measure umbilical artery blood flow.
Results: The results showed that a significant improvement in Doppler measurements and out come with treated groups (MgSO₄) group more than the control group.
Conclusion: MgSO₄ proved to cause many hemodynamic changes as it has a vasodilator effect on maternal and fetal blood vessels. Doppler indices in the umbilical arteries significantly changed after administration of MgSO₄ in patients with severe preeclampsia.