Background: Helicobacter pylori (H. pylori) infection is considered to be one of the most popular infections worldwide, affecting more than 50% of the world's population, principally in the developing countries. Objective: To determine the possible association between Helicobacter pylori infection and dysmetabolic syndrome in adult Egyptian population, principally cardio-metabolic components. Patients and Methods: Adult patients aged more than 18 years and presented with dysmetabolic syndrome or being metabolically healthy obese were enrolled in the study. All participants were subjected to meticulous history assessment and clinical evaluation. Results: An overall 60 patients who fulfilled the inclusion criteria were enrolled in the present study. Of them, 30 patients had metabolic syndrome, whereas the remaining 30 patients were metabolically healthy obese. There was a statistically significant difference between both groups regarding the levels of systolic and diastolic blood pressure, lipid profile, and glycemic status. There was an equal proportion of patients had positive Helicobacter Pylori infection among patients with metabolic syndrome and metabolically healthy obese patients. Furthermore, among patients with metabolic syndrome, correlation analysis revealed that; BMI showed a statistically significant positive correlation with Helicobacter Pylori infection. Conclusion: Helicobacter Pylori infection was highly prevalent infection in patients with metabolic syndrome. Metabolic syndrome patients with Helicobacter Pylori infection have higher blood glucose levels together with disturbed lipid profile. Being positively correlated with H. Pylori infection, patients with high BMI should be laboratory evaluated to role out the presence of Helicobacter Pylori infection.