Background: There is still limited data on the association between 25-hydroxyvitamin D, parathyroid hormone (PTH) and bone mineral density (BMD) in Egypt. Objective: To correlate between vitamin D level and bone mineral density in Egyptian patients with secondary hyperparathyroidism. Patients and Methods: Fifty female patients with secondary hyperparathyroidism recruited for the study from Rheumatology and Rehabilitation Outpatient Clinic of Al-Azhar University Hospitals, in addition to another fifty age matched control group healthy individuals after an informed consent from all subjects starting from November 2019 till may 2020. In this study, we measure parathormone hormone level, 25-Hydroxyvitamin D, serum calcium (total and ionized). Assessment of bone mineral density measured by dual-energy x-ray absorptiometry at lumbar spine, left proximal femur, and left distal forearm. Results: Lt Forearm BMD was significantly lower in the 50 women with secondary hyperparathyroidism than in the 50 with normal PTH levels. The mean t-score ± SD was -1.2 ± 0.93, and 0.5 ± 1.37 respectively. Thirty five (70%) was vit D deficient with mean t-score of the Lt Forearm -1.6 ± 1.48 (osteopenia), and fifteen (30%) was vit D insufficient with normal t-score of all bone parameters in this group. Conclusion: Our study revealed that positive correlation and significance between Vit D with serum calcium (total and ionized), BMD and t score (AP spine, Lt Femur, and Lt forearm), while negative correlation and significance between BMD (AP spine, Lt femur, and Lt forearm) with PTH, and negative correlation and significance between vit D with PTH.