Background: Obesity is considered a health hazard for metabolic disorders including diabetes mellitus (DM), dyslipidemia, hypertension and other related comorbidities. Laparascopic sleeve gastrectomy is considered more efficient bariatric procedure for weight loss compared with nonsurgical interventions. Single anastomosis sleeve ileal (SASI) bypass has been established as a new bariatric and metabolic procedure. Objective: To show metabolic disorders (DM, hyperlipidemia and hypertension) after SASI operation, and to detect short outcomes as regard weight loss and to assess complications as malnutrition. Patients and Methods: An interventional prospective study was carried at Bab Alshaariya university hospital, Cairo from May 2019 till November 2019.This study was conducted on 20 patients with body mass index (BMI) ≥ 48 kg/m2 underwent SASI bypass surgery and were followed for 6 months postoperatively. Changes in BMI, excess weight loss (EWL), routine lab investigations (FPG, HbAIC, triglyceride, cholesterol, HDL), and comorbidities improvement were recorded on six months follow-up post operation. Results: The main results of the study revealed that mean±SD age of the patients at the time of operation were 38.3 ± 3.61, mean BMI was 48.7 ± 7.6, 25% of cases were males and 75% were females. 65% of cases were diabetic, 40% hyperlipidmic, and 30% were hypertensive patients. There was a high significant difference between pre and post-surgery as regard FPG, HbAIC, triglyceride, cholesterol, HDL and LDL. There was a high significant difference between before and after surgery as regard BMI. Mean amount of blood loss was 76.1 ± 15.2 with a range of 50-150ml. During surgery, leak during methylene blue test was in 5% of cases, and no post-operative stenosis in cases. Conclusion: SASI bypass is an effective bariatric and metabolic surgery for achieving satisfactory weight loss in patients suffering other metabolic disorders with minimal surgical complications.