Background: The plasma kinetic technique that enables resection of the entire lobes of the prostate with physiologic saline irrigation seems to be a new option among minimally invasive surgical technique. Objective: To evaluate safety and efficacy of plasma kinetic resection of prostatic adenomas larger than 60 cc for symptomatic BPH. Patients and methods: It included 50 patients, from Al-Azhar university hospitals. They were submitted to full history taking, examination, and investigations before and after plasma kinetic resection of the prostate. Results: In the studied group preoperative Q-max ranged from 3.4 to13 with a mean of 7.60±2.80in patients presented with LUTS, while after intervention, it ranged from 14.1 to18.58 with a mean of 17.10±0.89; and a mean of 17.37±0.93 in patients with retention. There was significant increase after TURIS. IPSS score before intervention ranged from 16 to 30 with a mean of 21.94±4.36; while after intervention, it ranged from 2 to 16 with a mean of 8.82±4.06 and there was significant decrease after intervention. Quality of life score before intervention ranged from 3 to 6 with a mean of 4.46±1.16; while after intervention, it ranged from 1 to 4 with a mean of 1.74±0.82and there was significant decrease after intervention in comparison to their values before intervention. Conclusion: Plasma kinetic resection of the prostate provides a reasonable, safe and effective procedure for treatment benign prostatic hyperplasia.