Background: Proliferative diabetic retinopathy (PDR) is the most advanced stage of DR. It significantly increases the risk for progressive vision loss, and without intervention, approximately one half of eyes ultimately experience severe vision loss.      Although PRP is the gold standard treatment of PDR by reducing moderate visual loss by 50% in treatment groups, it also caused significant macular edema, which is recognized as the most common cause of decreased visual acuity in diabetic eyes. Optical Coherent Tomography (OCT) helps us studying these macular edema and its characteristics. Objective: To investigate the changes in macular thickness and morphology after panretinal photocoagulation (PRP) in eyes with proliferative diabetic retinopathy (PDR) and without clinically significant macular edema. Patients and Methods: This study enrolled 20 eyes of 15 patients with early proliferative diabetic retinopathy (PDR) without any clinically significant macular edema. Panretinal photocoagulation was applied 3 sessions, one week apart. Fundus fluorescein angiography and OCT were carried out for all patients before PRP. Baseline and post PRP visual acuity and central foveal thickness were evaluated after 3 months. Results: The mean patient age was 59.00±9.93 years (range, 33-72 years). Fifteen of the 20 eyes (75%) had stable or improved vision, while 5 eyes (25%) had worsened by 3 months following PRP. Mean preoperative vision was 0.50±0.1 decimal fraction, and although worsened at 3 months 0.48±0.15 decimal fraction, this was statistically insignificant (P = 0.453). Mean pre- PRP central foveal thickness was 253.05 ± 18.53 μm (ranging from 227 – 281μ), increased significantly to 281.45 ± 28.71 μm (ranging from 240 – 344μ) at 3 months' follow-up (P˂ 0.001). Three months after PRP, 15 eyes developed complications. The most common abnormality was cystoid edema seen in 6 eyes (30%), followed by diffuse macular edema in 4 eyes (20%), posterior vitreous detachment (PVD) in 2 eyes (10%), neuro sensory detachment in two eyes (10%), and epiretinal membrane (ERM) in one eye (5%). Conclusion: Panretinal photocoagulation is safe, effective in treating and preserving vision in proliferative diabetic retinopathy (PDR), although causing temporary drop in vision and changes in macular morphology/thickness.