Background: The single anastomosis sleeve ileal (SASI) bypass is a Novel Metabolic/Bariatric Surgery operation based on mini gastric bypass operation and Santoro's operation in which a sleeve gastrectomy is followed by a side to side gastro-ileal anastomosis. Objective: To evaluate the short-term outcomes between laparoscopic single anastomosis sleeve ileal bypass and mini gastric bypass, with respect to postoperative weight loss and metabolic and nutritional effects on patients. Patients and methods: This study was done at Al-AzharUniversityHospital and Al-NharHospital. It was a prospective randomized study which compared between single anastomosis sleeve ileum bypass (SASI bypass) Versus Laparoscopic Mini-gastric Bypass, in outcome. The study included 40 patients scheduled for elective laparoscopic bariatric surgery, due to morbid obesity, divided into two groups. The first group (group A) was operated by gastric mini bypass and the second group (group B) where single anastomosis sleeve ileum bypass was done. Results: The results of the study revealed that that there was high significant difference between before and after SASI surgery as regard FBG, HbAIC, triglycerides, cholesterol, HDL and LDL. Conclusion: SASI bypass is a promising operation that offers excellent weight loss and diabetic resolution.