Background: Early pregnancy loss is defined as loss of an intra_uterine pregnancy within the first trimester. Objective: To detect role of anti-oxidant supplementations in women with early pregnancy loss. Patients and methods: This clinical trial was conducted at Al-AzharUniversity, maternity Department, Assuit from January to March 2019. In this study, we selected a group of pregnant women (100) with history of recurrent early pregnancy loss up to 12 weeks. They were divided in to two equal groups (group A) received antioxidants supplementation (zinc, selenium, vitamin c and vitamin E) whereas (group B) received placebo. After procedure follow up of pregnant women was done. Results: In Group A, no significant relation between continuation of pregnancy and age of the mother, gestational age by date, gestational age by U/S, number of abortion and BMI, whether patient get pregnant naturally or by induction. In Group B, no significant relation between continuation of pregnancy and age of the mother, gestational age by date, gestational age by u/s, number of abortion, and BMI get pregnant naturally or by induction. Comparison of the Outcome of pregnancy beyond 12 weeks in the two study groups, in group A was 40 (80%) and 25 (50%) in group B with significant difference. Conclusion: Continuing pregnancy with antioxidants supplementation was more than those who received placebo (folic acid only).