Background: Polycystic ovary syndrome (PCOS) is complex with reproductive, metabolic and psychological features. It is characterized by chronic anovulation, biochemical and/or clinical evidence of hyperandrogenism and enlarged ovaries.
Objective: Is to evaluate the effect of ovarian drilling on the hormonal profile levels on blood in women with polycystic ovary syndrome. Hormonal profile including: Serum FSH, LH, E2, Prolactin and androgens (total &free testosterone and dehydroepiandrosterone sulfate (DHEA-S).
Patients and Methods: Fifty infertile women diagnosed with PCOS attending the infertility outpatient clinic at Syed Galal university hospital were selected for prospective interventional study. Hormonal assessment for FSH, LH, E2, prolactin and androgens (total & free test oster on and DHEA-S) were done before laparoscopic ovarian drilling (LOD), and 3month after LOD. Main outcome measures were changes in hormonal profile including LH, LH/FSH ratio, E2, Prolaction and androgens (total &free testosterone and DHEA-S).
Results: Laparoscopic ovarian drilling (LOD) was successfully employed without any surgical complications and on an average, follow-up time three months after the procedure. During the follow up, serum values for prolaction and E2 have increased significantly. (LH, LH/FSH ratio, total & free Testosterone and DHEA-S) have decreased significantly and FSH levels remained unchanged after the procedure.
Conclusion: The LOD in patients with PCOS may avoid or reduce the risk of OHSS and the multiple pregnancy rate induced by gonadotrophin therapy and the cost effectiveness of procedure after an attractive management for patients with PCOS. However, LOD can be considered as second line treatment after clomiphene citrate treatment failure and /or resistance.