Background: An atrophic scar is an indented scar that heals below the normal layer of skin tissue. Atrophic scars form when the skin is unable to regenerate tissue. As a result, it leaves behind imbalanced scarring. Objective: To evaluate the efficacy and safety of the autologous emulsified fat transfer with or without platelet rich plasma in the treatment of atrophic scar. Patients and methods: This study was carried out at Dermatology Department, Al-HusseinUniversityHospital, Faculty of Medicine, Al-AzharUniversity. This study included 60 patients with atrophic scar divided into 2 equal groups: group (A) treated with nanofat and platelet rich plasma, and group (B) treated with nanofat only. Scar in both groups caused by different etiological factors, their ages ranged from 19 to 59 years with 40 males and 20 females on a period from March 2019 to December 2019. Results: No significant differences between group A and group B after treatment, revealing that the corner stone of significance created by nanofat injection including adipose derived stem cells and growth factors without obvious clinical and statistical significance of additional platelet rich plasma. Conclusion: Nanofat injection has been shown to have beneficial effects in the treatment of atrophic scar, wrinkles, and skin discolorations, being highly effective in improving the height and pliability of all scars with mild improvement in pigmentation and vascularities, addition of platelet rich plasma to nanofat showed the same result which treated.