Background: Multiple sclerosis is an autoimmune inflammatory demyelinating disorder, affecting people in the most productive period in their lives with more predilection to affect females more than males, many demographic studies of multiple sclerosis had been done in many western countries, in the middle east particularly in Arabic countries multiple sclerosis now being heavily studied in all aspects ofthe disorder after the incidence of multiple sclerosis has been increased. Objective: The aim of this work  was to study the clinical and paraclinical characteristics of patients with multiple sclerosis (MS) attending Al-azhar university hospitals, (Al-Hussein and Bab-El-Sherya) along the time of the study (from April 2017 to April 2019) aiming for better management  and rehabilitation of Multiple sclerosis patients to improve their quality of life. Patients and Methods: This was a cross sectional descriptive study carried on 400 definite multiple sclerosis patients who were recruited from Al-Azhar university hospitals diagnosed according to revised McDonald's criteria 2017. Results: The current study included 400 MS patients, 113 were males and 287 were females, the main age of disease onset was 28.42±8.48, the motor manifestations was the most common presenting manifestation, followed by optic neuritis then the sensory manifestations, the relapsing remitting phenotype was the commonest phenotype, the family history of MS was positive in 2% in the current study, we observed a statistically significant difference between MS patients as regard MS phenotype and the sex of the patient, age and the total EDSS, first clinical symptoms and the total EDSS, time to 2nd clinical event and the total EDSS and the lesions in the spinal cord and the total EDSS. Conclusion: The first clinical presentation of MS affects the patient EDSS, patients with visual and sensory presentation had commonly lower EDSS, compared to patients with motor presentation had commonly higher EDSS.