Background: Diabetes mellitus is a growing metabolic disorder at a fast rate throughout the world, and it is the 16^th leading cause of global mortality. The significant anti-dyslipidemic effect of red Hibiscus extract may be safe and better alternative available over other agents in diabetic-associated dyslipidemia. Objective: Demonstrating the antioxidant property of Hibiscus in the role of reduction of blood glucose level. Material and Methods:  Sixty adult male albino rats were used in this study. The rats were divided into six equal groups, i.e.  control, alloxan-treated, hot red Hibiscus extract- treated cold red Hibiscus extract-treated, alloxan-treated plus hot red Hibiscus extract- treated and alloxan-treated plus cold red Hibiscus extract-treated groups. Blood samples were obtained for determination of serum glucose, insulin, total cholesterol, triglycerides, HDL- cholesterol, LDL-cholesterol as well as histopathological changes of the pancreas. Results: Treatment with red Hibiscus (hot and cold) extract was found to be effective in ameliorating lipid profile, blood glucose and insulin levels. Conclusion: The hypoglycemic, hypolipidemic and antioxidant properties of red Hibiscus were valuable in treatment of diabetes mellitus, and great consideration should be taken toward the use of Hibiscus as a complementary therapy beside ordinary anti-diabetic and hypolipidemic drugs.