Background: The introduction of direct acting anti virals hase increased sustained virological response (SVR) rates in chronic hepatitis C infection.  At present,  data on long-term durability of viral eradication after successful triple therapy are lacking. Objective: The predicators of durability of Sustained Virological response (S.V.R.) and its impact as pre-treatment markers. Patients and Methods: Sixty patients with chronic hepatitis C virus achieved S.V.R. (sustained virological response).   After 12 months of treatment, all patients were subjected to  D.M., H.T.N, any special habits like smoking, clinical examination, PCR for HCV, IL28B genotyping, Liver function tests, CBC and other associated diseases e.g. HIV ,HBV, Serum iorn concentration. Results: Several factors (host or viral-related factors or treatment related factors)  influenced  response to therapy and durability of S.V.R, advanced fibrosis, cirrhosis and steatosis have a negative impact on S.V.R. Also, IL28B genotyping can influence the durability of S.V.R. Patients with CC genotype were more likely to be cured by Peg-IFN and RBV, or  recent free INF therapy. Conclusions: Many factors can influence patients response to therapy and durability of SVR and IL28B  C/C genotype play a great role in  clearance of HCV.