Background: Colorectal cancer is incredibly common. It represents the 4^th leading cause of mortality and the second most common malignancy worldwide. With the advent of technological improvement, computed tomography (CT) became one of the important diagnostic tools in the evaluation of local characteristics, preoperative staging, and prognostic factors of colon cancer. Objective: In this study, we aimed to evaluate the role of contrast enhanced multidetector computed tomography (CEMDCT) in local staging of colorectal carcinoma (CRC). Patients and methods: MDCT was performed for 37 patients with pathologically proved CRC. All patients submitted to MDCT after IV nonionic iodinated intravenous contrast and oral and rectal positive or negative bowel opacification with water enema. The CEMDCT findings for each patient were recorded and correlated with operative and pathological findings as a reference standard. The sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy were calculated. Results: In the detection of extramural invasion, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy (DC) of CEMDCT were 89.5%, 77.8%, 81%, 87.5%, and 83.8% respectively. In the detection of lymph node status, the sensitivity, specificity, PPV, NPV, and AD were 88.9%, 78.9%, 80%, 68.2%, and 83.8%, respectively. In the detection of retroperitoneal surgical margin (RSM) involvement, the sensitivity was 75%, no false negative patient. Conclusion: CEMDCT is a sensitive tool in locoregional evaluation of colonic cancer.