Background: Interbody fusion represents an efficient surgical treatment in degenerative lumbar spine disorders, achieving satisfying outcome in >90% of cases. Various studies have affirmed the advantages of TLIF techniques with regard to achieve 360 degree fusion, but their efficacy in showing the results of TLIF in treatment of different lumbar spine degenerative disorders has not yet been demonstrated. Objectives: Assessing the clinical and radiological outcomes of transforaminal lumbar interbody fusion (TLIF) in the management of degenerative lumbar spine disorders, and to demonstrate the safety, surgical efficacy, and advantages of the transforaminal approach for lumbar interbody fusion. Patients and Methods: Twenty patients with degenerative lumbar spine disorders were treated with TLIF and were followed up for 18 months. The clinical outcomes were assessed by Visual Analog Scale (VAS) and Oswestry Disability Index (ODI) questionnaire. Results: Low back and leg pain completely resolved in 18 patients (90%).  Solid fusion was achieved in 18 patients (90%), whereas pseudarthrosis was documented in two patients. Complications reported post-operatively; Dural tear reported in 2 cases (10%), early post-operative wound infection reported in one case (5%), neurological deficitreported in one case (5%), Cage subsidence reported in one case (5%), Pseudo arthrosis reported in 2 cases (10%) and poor improvement of low back pain also reported in 2 cases (10%). Conclusions: TLIF is a safe and effective method in treatment of degenerative lumbar spine disorders for achieving circumferential spinal fusion via a single stage procedure.