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56634

EFFECTS OF ROSEMARY EXTRACT SUPPLEMENTATION ON ETHANOL INDUCED LIVER INJURY IN ADULT MALE ALBINO RAT

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Last updated: 22 Jan 2023

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Abstract

Background: Rosemary is a native Mediterranean small green herb. Its leaves contain many active constituents providing defense against oxidative stress from oxidizing agents and free radicals. The liver has a central role in the metabolism of many drugs. Chronic alcohol intake is associated with increasedoxidative stress and decreased antioxidant enzymes. Objective: Evaluation of the effects of Rosemary extract  supplementation on ethanol induced liver injury in adult male albino rats. Material and methods: Thirty adult male albino rats of local strain weighing 140 - 155 g were chosen to be the model of the present study.Theywere divided into three equal groups: Group I (Control group) received no treatment, Group II (Ethanol group) were subjected to induction of hepatotoxicity by daily administration of  45% liquid ethanol for six weeks, and Group III (Rosemary-treated group) were subjected to induction of hepatotoxicity and Rosemary supplementationfor six weeks. Blood samples were withdrawn, serum was separated for determination of ALT, AST, ALP, SOD and MDA serum levels. Rats were killed and pelvi-abdominal cavities were opened. Livers were excised for studying histopathological changes. Results: Ethanol administration was associated with significant changes in the  liver functions indicated by elevated serum liver enzymes and distorted liver morphology associated with disturbed oxidant-antioxidant status as indicated by elevated serum MDA and decreased SOD levels. These changes were improved by Rosemary administration but however, these improvements did not reach the basal level. Conclusion: Ethanol administration markedly disturbed the liver functions. Rosemary administration has a hepatoprotective effects against these changes.

DOI

10.12816/0038260

Keywords

rosemary, alcoholic liver disease, oxidants-antioxidants

Authors

First Name

Shebl

Last Name

Ramadan Samaha

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Affiliation

Medical Physiology Department, Faculty of Medicine, Al-Azhar University

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Volume

46

Article Issue

2

Related Issue

8497

Issue Date

2017-04-01

Receive Date

2017-04-01

Publish Date

2017-04-01

Page Start

373

Page End

382

Print ISSN

1110-0400

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https://amj.journals.ekb.eg/article_56634.html

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https://amj.journals.ekb.eg/service?article_code=56634

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8

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Original Article

Type Code

941

Publication Type

Journal

Publication Title

Al-Azhar Medical Journal

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https://amj.journals.ekb.eg/

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Article

Created At

22 Jan 2023