Background: Stand-alone anchored spacers aim at reducing complications associated with traditional plating while maintaining the functionality of interbody spacer and plating. Objective: We prospectively followed up patients who underwent anterior cervical discectomy and fusion (ACDF) in single or multiple levels using the polyetheretherketone (PEEK) prevail cervical interbody device. Patients and Method: Prospective study of 24 patients suffering from single or multiple level degenerative cervical disc diseases from C3-C4 to C7-T1, operated at Al-Agouza spine hospital, between September 2013 to August 2015. All patients underwent surgery using PEEK prevail device. Patients were evaluated using visual analogue score (VAS) for neck pain, VAS for arm pain, and neck disability index (NDI) scores. Clinical improvement was also graded by Odom's criteria at final follow up. Result: The study showed a statistically significant difference between pre and post-operative as regard VAS for neck pain and arm pain of the study group. Also, there was a statistically significant difference between pre- and post-operative as regard neck disability index of the study group.   Conclusion: The use of stand-alone cages in anterior cervical decompression and fusion provided short time clinical improvement with minimal complication rates.