Background: Jaundice is one of the commonest problems that can occur in a newborn. It affects more than 60% of late preterm and term newborns, peaking at 3–5 days of life many time. It is physiological in the newborn because liver is not mature enough to handle the bilirubin and usually resolving by 2 weeks of age. Objectives: The aim of this work was to evaluate if cord blood albumin levels are useful in predicting the development of jaundice in neonates. Subjects and Methods: This prospective study was conducted on 60 neonates. They were classified into 2 groups, group I (30 neonates with high risk factors for neonatal jaundice) as cases group and group II (30 neonates without any risk factor for neonatal jaundice) as a control group. Cord blood was collected from the newborns for cord serum albumin level measurement. Total serum bilirubin  was measured directly after  birth and 4^th day of life. Results: In the present study, there was significant inverse correlation between cord albumin level and serum bilirubin level in 4^th day in the case group. Also, there was asignificant inverse correlation between cord albumin level and serum bilirubin level in 4^th day in control group. Conclusion: Umbilical cord albumin levels are useful as a screening test in predicting the development of hyperbilirubinemia in neonates. It will help to detect infants at low or high risk for hyperbilirubinemia. This will minimize hospitalization and prevent readmission of infants with jaundice.