Background: Resveratrol, an antioxidant compound, known to be used for the attenuation of the pro-oxidant effects of toxicants. Objectives: Evaluation of the anti-inflammatory and antioxidant impact of resveratrol in treatment of arthritis in rats. Materials and Methods: Rats were assigned into five groups: negative control, positive control (arthritis was induced by freund's complete adjuvant), arthritic rats received celecoxib (30mg/kg, p.o), arthritic rats received resveratrol (50mg/kg, p.o.), and arthritic rats received combination of both drugs (10 rats/ each group). Results: Arthritis significantly elevated cyclooxygenase-2, interleukin-1β, tumor necrosis factor-α, lysosomal enzymes, some biochemical liver parameters, and decreased caspase 3activity in serum and significantly increased myeloperoxidase, malondialdhyde and nitric oxide levels: reduced glutathione contents in paw tissues and albumin level in blood serum. The treatment combination of resveratrol with celecoxib induced an additive anti-inflammatory, biochemical and antioxidant effects. Conclusion: Resveratrol potentiates the anti-inflammatory and antioxidant effects of celecoxib in adjuvant induced arthritis.