Background: Esophageal varices (EV), a major complication of liver cirrhosis, can lead to life threatening through gastrointestinal (GI) bleeding. Early detection of EV and prediction of its bleeding risk is important. Objectives: Evaluate the resistive index (RI) of the renal artery (RA) and splenic artery by Doppler in various stages of liver cirrhosis, and their values for detection of EV and its bleeding. Patients and Methods: This study included Sixty six patients with confirmed diagnosis of LC, twenty two patients with esophageal varices and having history of variceal bleeding episodes, twenty four patients with esophageal varices and having no variceal bleeding episodes history, and twenty patients without esophageal varices. All patients were subjected to history taking, clinical examination, laboratory investigations, calculation of some important non-invasive indices (CHILD, FIB 4, and APRI), abdominal ultrasonography, renal and splenic artery Doppler, and Upper GI endoscopy. Results: RA RI served as predictors of the presence as well as bleeding risk of esophageal varices, and this prediction capability further empowered when both LRA RI and RRA RI were incorporated in a prediction equation, predicting the presence of esophageal varices with 95.7%, sensitivity and 50 % specificity at a cut off value of 0.715. Also, LRA RI revealed a sensitivity of 81.8%, and a specificity of 50% at the cut off value of 0.725 for prediction of esophageal varices bleeding. The splenic artery resistive index revealed a sensitivity of 69.6%, and a specificity of 90.1% for prediction of esophageal varices in a cut off value of 0.715 and a sensitivity of 68.2%, and a specificity of 70.5% for prediction of esophageal varices bleeding in a cut off value of 0.725. Conclusion: Resistive index of the renal artery may help in predictions of esophageal varices and its bleeding risk, LRA RI was more sensitive for prediction of esophageal varices bleeding. In contrast, the splenic artery was less sensitive for prediction of esophageal varices and its bleeding risk.