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55594

LISINOPRIL VERSUS AMLODIPINE IN HYPERTENSIVE PATIENTS SUBJECTED FOR ANESTHESIA

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Last updated: 22 Jan 2023

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Abstract

Background: Hypertension is regarded as an additional risk factor during anesthesia. Antihypertensive usage and its implications during perioperative period have unpredictable effects on hemodynamics. Objectives: To evaluate the effect of anesthesia (general) on hemodynamics in hypertensive patients chronically treated with amlodipine in comparison to patients on lisinopril. Patients and Methods: This study included sixty adults, of both sexes, aged between 40 and 60 years old, controlled hypertensive with amlodipine or lisinopril, randomly divided into four equal groups. Group AG: On amlodipine subjected for general anesthesia, Group AS: On amlodipine subjected for spinal anesthesia, Group LG: On lisinopril subjected for general anesthesia, Group LS: On lisinopril subjected for spinal anesthesia, scheduled for elective lower limb or lower abdominal surgeries. Monitoring of arterial blood pressure (SBP, DBP, MAP), HR, oxygen saturation were recorded as pre-operative basal reading , immediately after induction, every 5 minutes for 20 minutes, then every 15 minutes till the end of operation. Hypertension was considered when increase >20% from basal reading, and hypotension when decrease <20% from basal reading. Results: There were statistically significant differences as regard systolic, diastolic, mean arterial blood pressure between group AS and group LS with significant decrease in SBP, DBP, MAP more in group LS after spinal injection, also there were statistically significant differences as regard systolic, diastolic, mean arterial blood pressure between group AG and group LG with significant decrease in SBP, DBP, MAP more in group AG after induction of anesthesia. Also, there was astatistically significant difference as regard heart rate between AS and LS groups with significant  decrease in HR more in group AS after spinal injection than LS group, Statistical significant difference was noticed in heart rate between AG and LG groups with significant  decrease in HR more in group LS after induction of anesthesia. Conclusion: Amlodipine was better than lisinopril in its effect regarding hemodynamics in hypertensive patients subjected for anesthesia.

DOI

10.12816/0052818

Keywords

Hypertension, amlodipine, lisinopril

Authors

First Name

Tawfik

Last Name

M. Tawfik Noor-Eldin

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Affiliation

Department of Anesthesia and Intensive Care, Faculty of Medicine, Al-Azhar University, Cairo

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Orcid

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First Name

Mohamed

Last Name

Samey Sharaf

MiddleName

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Affiliation

Department of Anesthesia and Intensive Care, Faculty of Medicine, Al-Azhar University, Damietta

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First Name

Abd

Last Name

El-Wahab Abd-Esattar Saleh

MiddleName

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Affiliation

Department of Anesthesia and Intensive Care, Faculty of Medicine, Al-Azhar University, Cairo

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First Name

Abd-Allah

Last Name

Mohamed Abd-Allah

MiddleName

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Affiliation

Department of Anesthesia and Intensive Care, Faculty of Medicine, Al-Azhar University, Cairo

Email

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City

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Orcid

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First Name

Mohamed

Last Name

Gameel Mohamed Yousef

MiddleName

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Affiliation

Department of Anesthesia and Intensive Care, Faculty of Medicine, Al-Azhar University, Damietta

Email

mohamed.gimi14@gmail.com

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Orcid

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Volume

47

Article Issue

3

Related Issue

8448

Issue Date

2018-07-01

Receive Date

2018-07-01

Publish Date

2018-07-01

Page Start

561

Page End

572

Print ISSN

1110-0400

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https://amj.journals.ekb.eg/article_55594.html

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https://amj.journals.ekb.eg/service?article_code=55594

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10

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Original Article

Type Code

941

Publication Type

Journal

Publication Title

Al-Azhar Medical Journal

Publication Link

https://amj.journals.ekb.eg/

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Article

Created At

22 Jan 2023