Background: Anal surgery is associated with severe postoperative pain which is a source of such anxiety that some patients refuse the operation. Opiates and non-steroidal anti-inflammatory drugs have often been used to control pain. Objectives: Evaluation of the effect of diclofenac suppository and lignocaine cream on postoperative pain after anal surgery. Paitents and Methods: This study was a prospective randomized double blinded controlled study carried on 120 patients presenting with anal conditions (hemorrhoid, anal fissure or low perianal fistula), who underwent anal surgery. Patients were divided randomly into two equal groups. Group (A) was a control group, and group (B) received diclofenac suppository (100 mg) and topical lignocaine cream 5% (5 g) at the end of surgery. The mean VAS scores at 2, 4, 8, 12, and 24 hours after surgery were recorded. Results: The pain reported by group (B) was statistically lower than that in control group (group A) in all intervals. Also, the incidence for administration of postoperative analgesic in group (B) was statistically lower than that in group (A). Conclusion: Combination of diclofenac suppository and topical lignocaine cream significantly decreased the severity of postoperative pain after anal surgery, and decreased the requirement of post-operative analgesics.