Background: Diabetes mellitus and the associated complications represent a global burden on human health and economics. Cardiovascular diseases are one of the leading causes of death in diabetic patients. Arabic gum (AG) is a natural compound that has a potent anti-inflammatory effect, antioxidant activity, and hypoglycemic effect. Objective: Evaluation of the effects of Arabic gum on diabetic cardiomyopathy (DCM). Material and Methods: Thirty-two adult male albino rats of a local strain were chosen as an animal model for this study, weighed 110 -130 g (average weight was 120 g). Diabetes mellitus type II was induced in experimental rats by using a high-fat diet (HFD) for two weeks followed by streptozotocin (STZ) injection. At the end of the experiment (8 weeks), serum was obtained for the determination of glucose, insulin, cardiac enzymes (lactate dehydrogenase,creatine kinase-MB fraction and AST), lipid profile (triglycerides and total cholesterol), and oxidative stress markers (Thiobarbituric acid-reactive substance and superoxide dismutase). ECG was recorded. Also, heart weight/body weight ratio (HW/BW) was calculated at the end of the experiment. Results: Diabetic rats exhibited hyperglycemia, and hyperlipidemia accompanied by significant hypoinsulinemia. In addition, diabetic rats showed significantly increased HW/BW, serum CK-MB, AST, and lactate dehydrogenase. Oxidative stress marker increased, whereas antioxidant defenses significantly reduced in the diabetic heart. ECG also disturbed. Treatment with Arabic gum alleviated hyperglycemia, hyperlipidemia, and heart function markers. Arabic gum also minimized the oxidative stress and boosted antioxidant defenses in the heart of diabetic rats. HW/BW decreased and ECG ameliorated. Conclusion: Arabic gum attenuated the development of DCM via amelioration of hyperglycemia/hyperlipidemia-mediated oxidative stress. Therefore, it might be worth considering the therapeutic potential of AG for human DCM.