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Evaluation of the Protective Effect of Silymarin and Nano Encapsulation of Ginger Extract on Hepatotoxicity in Adult Male Albino Rats

Article

Last updated: 04 Jan 2025

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-

Tags

Clinical Research (Medical)

Abstract

Abstract
Background: Antioxidant effect of herbal products like Silymarin & Ginger can get rid of free radicals. Nanoparticles can reach the target easily without inactivation, increase the bioavailability of the therapy and reduce its toxicity. Aim:To evaluate the protective effect of silymarin and nano-encapsulation of Ginger extract on hepatotoxicity in adult male albino rats. Materials and Methods: Eighty rats were randomized into eight groups (10 rats each).Group I (control): subdivided into 3 control subgroups; Group II: rats received nano-encapsulation of ginger extract 50 mg/kg/day by oral gavage every day. Group III: rats received 0.1 ml/100 gm/kg of Ccl4 dissolved in corn oil (1:1) twice a week by intraperitoneal injection. Group IV:Silymarin was given in a dose of 200 mg/kg/day dissolved in one ml distilled water by oral gavage every day with Ccl4. Group V: nano-encapsulation of ginger 50 mg/kg/day by oral gavage every day Ccl4. Group VI: the doses were administrated as in groups II, III &IV for six weeks in all groups. At the end of the experiment, rats were anesthetized, blood samples collected for ALT and AST measurement then sacrificed and the liver was excised, for SOD, H&E, and histoimmunological studies. Results: Ccl4-induced hepatotoxicity can be protected by silymarin or/and nano-encapsulation of ginger that showed more improvement than silymarin in histopathological and immunohistochemical, morphometric, SOD, ALT, and AST results. Conclusion: The study found that hepatotoxicity can be protected by the administration of silymarin or/and nano-encapsulation of ginger extract. Nano-encapsulation of the ginger extract showed more improvement than silymarin.
 

DOI

10.21608/scumj.2022.270511

Keywords

Liver, experimental, Nano, Immunohistochemical, Antioxidant enzymes

Authors

First Name

Clara

Last Name

Kerolus

MiddleName

E.

Affiliation

Department of Human Anatomy and Embryology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Bassma

Last Name

Dessouki

MiddleName

M.

Affiliation

Department of Human Anatomy and Embryology, Faculty of Medicine, Suez Canal University, Egypt

Email

bassmadesouky@gmail.com

City

-

Orcid

-

First Name

Gamal

Last Name

Abdel-Rahman

MiddleName

M.

Affiliation

Department of Human Anatomy and Embryology, Faculty of Medicine, Suez Canal University, Egypt

Email

abdulrahman.200@hotmail.com

City

-

Orcid

-

First Name

Noha

Last Name

Salem

MiddleName

A.

Affiliation

Department of Human Anatomy and Embryology, Faculty of Medicine, Suez Canal University, Egypt

Email

noha2805@hotmail.com

City

-

Orcid

-

Volume

25

Article Issue

4

Related Issue

37696

Issue Date

2022-12-01

Receive Date

2022-11-20

Publish Date

2022-12-01

Page Start

19

Page End

33

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 25_Issue 4_Pages 19-33.pdf

PDF . 1.1MB

Link

https://scumj.journals.ekb.eg/article_270511.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=270511

Order

3

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Evaluation of the Protective Effect of Silymarin and Nano Encapsulation of Ginger Extract on Hepatotoxicity in Adult Male Albino Rats

Details

Type

Article

Created At

22 Jan 2023