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262844

Assessment of Retinal Nerve Fiber Layer and Ganglion Cell Complex Thickness in Myopic versus Emmetropic Children attending Ophthalmology Outpatient Clinic in Suez Canal University

Article

Last updated: 04 Jan 2025

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Clinical Research (Medical)

Abstract

Background: OCT is a useful tool for differentiating early stages of glaucoma in children as well as adults. Having a normative reference range for children helps in detecting such serious disease and treating it in earlier phases however, children's normative data are not provided by the OCT software. Aim: to share and establish reference values and data about retinal nerve fiber layer and ganglion cell complex thickness in the child age group, helping later-on earlier detection of disorders that possess damaging effects on such layers as glaucoma. Patients and Methods: one hundred thirty-five children were enrolled and divided into two groups, group A including all emmetropic children with spherical equivalent between ≥ -1 and ≤ +1 diopter and group B including all myopic children with spherical equivalent between (≤ -1 and up to - 6 diopter)Measurement of retinal nerve fiber RNFL and ganglion cell complex GCC layer thickness using OCT scans were done using DRI OCT Triton plus. Results: Total retinal nerve fiber layers were thinner among the myopic group (106.2±5.65µm) than emmetropic group (111.7±6.39µm) (p < 0.001). The total ganglion cell complex layer was thinner among the myopic group (65.99±2.72µm) than emmetropic group (70.22±2.84µm) (p < 0.001). All RNFL and GCC thickness measurements showed significant indirect weak correlations with age. There is a significant correlation between axial length with (superior RNFL, average RNFL, superior GCC, inferior GCC, and total average GCC measurements). But no significant correlations were found between AL with Inferior RNFL thickness and age. Conclusion: Our study clearly demonstrates that myopic eyes have a thinner RNFL and GCC than emmetropic eyes. On one hand, this thinning may be a risk factor for glaucoma development, as variations in the arrangement of optic nerve head fibers have been postulated to render myopic eyes more susceptible to glaucomatous damage.  

DOI

10.21608/scumj.2022.262844

Keywords

OCT, RNFL, GCC

Authors

First Name

Mariam

Last Name

Abouelfadl

MiddleName

-

Affiliation

Department of Ophthalmology, Faculty of Medicine, Suez Canal University, Egypt

Email

mariamalielsayed@gmail.com

City

Ismailia

Orcid

-

First Name

Mohamed

Last Name

Shahin

MiddleName

E.

Affiliation

Department of Ophthalmology, Faculty of Medicine, Suez Canal University, Egypt

Email

meeishahin@gmail.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Mohamed

MiddleName

M.

Affiliation

Department of Ophthalmology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

Volume

25

Article Issue

3

Related Issue

36846

Issue Date

2022-10-01

Receive Date

2022-10-02

Publish Date

2022-10-01

Print ISSN

1110-6999

Online ISSN

2090-2581

Link

https://scumj.journals.ekb.eg/article_262844.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=262844

Order

10

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Assessment of Retinal Nerve Fiber Layer and Ganglion Cell Complex Thickness in Myopic versus Emmetropic Children attending Ophthalmology Outpatient Clinic in Suez Canal University Hospital

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Type

Article

Created At

22 Jan 2023