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262246

Assessment of Serum Interleukin 8 in Hepatitis C-related Cirrhosis with Itching

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Last updated: 04 Jan 2025

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Clinical Research (Medical)

Abstract

Background: Interleukin-8 (IL-8) has a role in the pathophysiology of pruritus. However, there hasn't been much research into the link between IL-8 and cirrhosis caused by the hepatitis C virus (HCV) and itching. The goal of this study was to investigate the amount of IL-8 in patients with itching caused by post-HCV liver cirrhosis. Patients and Methods: The study included 60 patients with HCV-related cirrhosis of varying severity according to the Child-Pugh classification and 30 healthy control subjects who were matching the study group for age and sex. Data were gathered during the history, clinical examination, laboratory investigations, abdominal ultrasonography, and outcome measures (Child-Pugh classification, 5-D pruritus scale, and IL-8 assessment by enzyme-linked immunosorbent assay). Results: Child C patients had a substantially higher pruritus score than Child A and B patients (10.72±2.83 versus 8.35±3.48 and 8.77±2.98, respectively) (p < 0.05). Cirrhotic patients had a considerably higher mean level of IL-8 than healthy controls (150.8±40.9 versus 35.1±5.4, respectively) (p < 0.0001). The mean values of IL-8 in Child C patients were substantially higher than in Child B and Child A patients (181.6±13.8 versus 156.3±17.4 and 84.3±29.1, respectively) (p < 0.0001). Conclusions: Child C patients had considerably greater pruritus scores and IL-8 levels than Child A and B patients. Cirrhotic individuals had significantly greater mean levels of IL-8 than healthy controls. In the investigated patients, there was a strong positive correlation between IL-8 levels and pruritus scores.  

DOI

10.21608/scumj.2022.262246

Keywords

Child-Pugh classification, predictive values, pruritus score

Authors

First Name

Lina

Last Name

Atef

MiddleName

M.

Affiliation

Department of Dermatology and Venereology, Faculty of Medicine, Suez Canal University

Email

-

City

-

Orcid

-

First Name

Marwa

Last Name

Ali

MiddleName

A.

Affiliation

Department of Dermatology and Venereology, Faculty of Medicine, Suez Canal University

Email

-

City

-

Orcid

-

First Name

Amal

Last Name

Ahmed

MiddleName

A.

Affiliation

Department of Dermatology and Venereology, Faculty of Medicine, Suez Canal University

Email

-

City

-

Orcid

-

First Name

Nader

Last Name

Nemr

MiddleName

A.

Affiliation

Department of Endemic and Infectious Diseases, Faculty of Medicine, Suez Canal University

Email

-

City

-

Orcid

-

Volume

25

Article Issue

3

Related Issue

36846

Issue Date

2022-10-01

Receive Date

2022-09-30

Publish Date

2022-10-01

Print ISSN

1110-6999

Online ISSN

2090-2581

Link

https://scumj.journals.ekb.eg/article_262246.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=262246

Order

6

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Assessment of Serum Interleukin 8 in Hepatitis C-related Cirrhosis with Itching

Details

Type

Article

Created At

22 Jan 2023