Subjects
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Clinical Research (Medical)
Abstract
Background: Autism Spectrum Disease (ASD) is a complex developmental disorder. Children with autism spectrum disorder have low serum levels of L-carnitine. Aim:We aimed at assessing the reliability of using the serum level of L-carnitine as a biomarker in children with ASD. Subjects and Methods: This is a case-control study conducted on 60 children at the outpatient Neurobehavioral Clinic of Alexandria University Children's Hospital (AUCH), divided into 2 groups. Group 1 (research group): 30 children diagnosed with ASD and Group 2 (control group): 30 healthy children. Children of both groups were subjected to history taking, clinical neurological examination, Childhood autism rating scale (CARS), and serum carnitine level measurement. Results: The mean serum level of L-carnitine in children with ASD was significantly lower in cases than in control children. No statistically significant correlation between low levels of serum L-carnitine and gender was detected in the patients' group. The severity of ASD symptoms had a non-significant correlation with levels of L- carnitine. Conclusion: Serum L-carnitine can be considered a biochemical metabolic marker for mitochondrial dysfunction in children with ASD.
DOI
10.21608/scumj.2022.251408
Keywords
CARS, Biological Marker, ASD, Mitochondrial dysfunction, Repetitive Behavior
Authors
Affiliation
Department of Pediatrics, Faculty of Medicine, Alexandria University, Egypt
Email
shimaa.anwar@gmail.com
City
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Department of Pediatrics, Faculty of Medicine, Alexandria University, Egypt
Email
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Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Egypt
Email
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Department of Pediatrics, Ministry of Health, Alexandria, Egypt
Email
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-Link
https://scumj.journals.ekb.eg/article_251408.html
Detail API
https://scumj.journals.ekb.eg/service?article_code=251408
Publication Title
Suez Canal University Medical Journal
Publication Link
https://scumj.journals.ekb.eg/
MainTitle
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