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251408

Study of Serum Level of L-Carnitine in Children with Non-Syndromic Autism Spectrum Disorder: A Biological Metabolic Marker

Article

Last updated: 04 Jan 2025

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-

Tags

Clinical Research (Medical)

Abstract

Background: Autism Spectrum Disease (ASD) is a complex developmental disorder. Children with autism spectrum disorder have low serum levels of L-carnitine. Aim:We aimed at assessing the reliability of using the serum level of L-carnitine as a biomarker in children with ASD. Subjects and Methods: This is a case-control study conducted on 60 children at the outpatient Neurobehavioral Clinic of Alexandria University Children's Hospital (AUCH), divided into 2 groups. Group 1 (research group): 30 children diagnosed with ASD and Group 2 (control group):  30 healthy children.  Children of both groups were subjected to history taking, clinical neurological examination, Childhood autism rating scale (CARS), and serum carnitine level measurement. Results: The mean serum level of L-carnitine in children with ASD was significantly lower in cases than in control children. No statistically significant correlation between low levels of serum L-carnitine and gender was detected in the patients' group. The severity of ASD symptoms had a non-significant correlation with levels of L- carnitine. Conclusion: Serum L-carnitine can be considered a biochemical metabolic marker for mitochondrial dysfunction in children with ASD.

DOI

10.21608/scumj.2022.251408

Keywords

CARS, Biological Marker, ASD, Mitochondrial dysfunction, Repetitive Behavior

Authors

First Name

Shimaa

Last Name

Anwar

MiddleName

A.M.

Affiliation

Department of Pediatrics, Faculty of Medicine, Alexandria University, Egypt

Email

shimaa.anwar@gmail.com

City

-

Orcid

0000-0002-7089-5925

First Name

Hussein

Last Name

Abdeldayem

MiddleName

H.

Affiliation

Department of Pediatrics, Faculty of Medicine, Alexandria University, Egypt

Email

-

City

-

Orcid

-

First Name

Magdy

Last Name

El-Bordiny

MiddleName

M.

Affiliation

Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Egypt

Email

-

City

-

Orcid

-

First Name

Maha

Last Name

Kamel

MiddleName

S.

Affiliation

Department of Pediatrics, Ministry of Health, Alexandria, Egypt

Email

-

City

-

Orcid

-

Volume

25

Article Issue

2

Related Issue

31648

Issue Date

2022-07-01

Receive Date

2022-07-27

Publish Date

2022-07-01

Page Start

77

Page End

86

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 25_Issue 2_Pages 77-86.pdf

PDF . 352.8kB

Link

https://scumj.journals.ekb.eg/article_251408.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=251408

Order

10

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Study of Serum Level of L-Carnitine in Children with Non-Syndromic Autism Spectrum Disorder: A Biological Metabolic Marker

Details

Type

Article

Created At

22 Jan 2023