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251082

Immune Thrombocytopenia in Children: What is the Role of Interleukin-4 and Tumor Necrosis Factor-Alpha?

Article

Last updated: 22 Jan 2023

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Tags

Clinical Research (Medical)

Abstract

Background: Immune thrombocytopenia (ITP) is a common acquired autoimmune disease in which autoantibody-coated platelets induce phagocytosis by macrophages. Complex immune dysregulation including Th1/Th2 imbalance is involved in the pathogenesis of this disease. Tumor necrosis factor-alpha (TNF-α) and interleukin 4 (IL-4) are cytokines produced by T cells and have various inflammatory, and immunomodulatory activities. Aim: To detect the changes in the level of TNF-α and IL-4in children with immune thrombocytopenia, and to correlate their levels with the disease course, severity, and response to treatment. Subjects and Methods: This is a case-control study that enrolled 100 subjects divided into 2 groups; patients' group: children with ITP and age- and gender-matched normal subjects as control. All participants were subjected to complete blood count, assessment of serum TNF-α, and IL-4 using ELISA technique. Results: There was a non-significant difference between patients and control groups (p < /em>-value 0.283) in serum IL-4; moreover, there was a non-significant difference in IL-4 levels among different severity grades of ITP. On the other hand, serum TNF-α was significantly higher in the patients' group than in the control group (p < /em>-value 0.002). Both TNF-α and IL-4 levels were significantly higher in newly diagnosed patients. Conclusion: TNF-α levels increase in patients with ITP. TNF- α and IL-4 are significantly higher in patients with newly diagnosed ITP.
 

DOI

10.21608/scumj.2022.251082

Keywords

Immune Dysregulation, T helper cells, ITP, TNF- α, IL-4

Authors

First Name

Samar

Last Name

Elfiky

MiddleName

-

Affiliation

Department of Pediatrics, Faculty of Medicine, Suez Canal University, Egypt.

Email

dr_samar.elfiky@yahoo.com

City

-

Orcid

-

First Name

Hesham

Last Name

Elsayed

MiddleName

F.

Affiliation

Department of Pediatrics, Faculty of Medicine, Suez Canal University, Egypt.

Email

heshamfatheyelsayed@gmail.com

City

-

Orcid

0000-0003-3012-6707

First Name

Lyla

Last Name

Ezz

MiddleName

A.

Affiliation

Department of Pediatrics, Faculty of Medicine, Suez Canal University, Egypt.

Email

-

City

-

Orcid

-

First Name

Amany

Last Name

Moustafa

MiddleName

KH.

Affiliation

Department of Pediatrics, Faculty of Medicine, Suez Canal University, Egypt.

Email

dramanykhaled01@gmail.com

City

-

Orcid

-

First Name

Nevene

Last Name

Wissa

MiddleName

R.

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Amany

Last Name

Hassan

MiddleName

M.

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

Volume

25

Article Issue

2

Related Issue

31648

Issue Date

2022-07-01

Receive Date

2022-07-24

Publish Date

2022-07-01

Page Start

68

Page End

76

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 25_Issue 2_Pages 68-76.pdf

PDF . 292.2kB

Link

https://scumj.journals.ekb.eg/article_251082.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=251082

Order

9

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023