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249731

Interleukin-36α Expression in Vitiligo Skin Lesions and Its Association with Disease Pattern, Activity, and Severity

Article

Last updated: 04 Jan 2025

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Subjects

-

Tags

Clinical Research (Medical)

Abstract

Background: Vitiligo is a pigmentary disorder defined by the presence of well-circumscribed milky-white macules on the skin and mucous membranes caused by the loss of functional melanocytes in the affected areas. There are various theories for vitiligo's origin, including neurological, auto cytotoxic, genetic, and immunological theories. Because the cytokine IL-36 is involved in the development and pathophysiology of autoimmune disorders such as psoriasis, rheumatoid arthritis, and SLE, it's probable that IL-36 plays a role in the progression of vitiligo. Objectives: The purpose of this study was to look at the tissue expression of IL-36 in vitiligo lesions and non-lesional skin. Patients and Methods: There were 41 vitiligo patients and 5 healthy controls in this cross-sectional analytic study. Each patient's history was collected, and all patients were examined by a dermatologist to determine the pattern, activity, and severity of vitiligo. Biopsies were extracted from lesional and nonlesional skin of all patients, and immunohistochemistry staining for IL-36 expression was performed. Results: In vitiligo patients, IL-36 expression was elevated in both lesional and nonlesional skin, primarily in the inflammatory infiltrate in the dermis. In terms of age of onset, sex, disease duration, course, activity severity, and pattern, there is no significant variation in IL-36 expression. Conclusion: Our findings suggested that IL 36 may have a role in the etiology of vitiligo, which could shed light on the disease's pathogenesis.
 

DOI

10.21608/scumj.2022.249731

Keywords

IL-36α, interleukin 36α, interleukin 36, Vitiligo, disease severity

Authors

First Name

Lina

Last Name

Atef

MiddleName

-

Affiliation

Department of Dermatology and Venereology, Faculty of Medicine, Suez Canal University

Email

lina_atef@yahoo.com

City

ismailia

Orcid

0000-0003-2455-8669

First Name

Sahar

Last Name

Mansour

MiddleName

F.

Affiliation

Department of Pathology, Faculty of Medicine, Suez Canal University.

Email

sfmansour36@gmail.com

City

-

Orcid

-

First Name

Rasha

Last Name

Ibrahim

MiddleName

M.

Affiliation

Department of Dermatology and Venereology, Faculty of Medicine, Suez Canal University

Email

-

City

-

Orcid

-

First Name

Mona

Last Name

Atwa

MiddleName

A.

Affiliation

Department of Dermatology and Venereology, Faculty of Medicine, Suez Canal University

Email

atwamona@gmail.com

City

-

Orcid

-

Volume

25

Article Issue

2

Related Issue

31648

Issue Date

2022-07-01

Receive Date

2022-07-19

Publish Date

2022-07-01

Page Start

40

Page End

47

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 25_Issue 2_Pages 40-47.pdf

PDF . 383.7kB

Link

https://scumj.journals.ekb.eg/article_249731.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=249731

Order

6

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Interleukin-36α Expression in Vitiligo Skin Lesions and Its Association with Disease Pattern, Activity, and Severity

Details

Type

Article

Created At

22 Jan 2023