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223250

Effect of Intravitreal Injection of Ranibizumab on Macular Perfusion by Optical Coherence Topography Angiography

Article

Last updated: 22 Jan 2023

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Tags

Clinical Research (Surgical)

Abstract

Background:Diabetic retinopathy (DR), diabetic microangiopathy, is characterized by capillary nonperfusion, which increases the expression of vascular endothelial growth factor (VEGF). Intravitreal ranibizumab injection was approved for the treatment of diabetic macular edema. Objective: Assessment of the efficacy of intravitreal injection of ranibizumab on macular perfusion. Patients and Methods: Quasi-experimental interventional study was undertaken at Suez Canal University hospitals, Ophthalmology Department on patients who were diagnosed as having diabetic macular edema by optical coherence topography. A total of 60 participants were evaluated by taking a complete ophthalmologic history, examination, and investigations by the use of a pre-designed checklist,and intravitreal injection of anti-VEGF was done. Results: Our study showed that the study group has consisted of 71.4% females and 28.3% males. The mean ± SD of the average superficial foveal avascular zone (sFAZ) area was 263.33 ± 61.80 µm2 pre-injection, 208.33 ± 40.41 post-injection with an improvement of 55.0 ± 21.39 (20.22%). The mean ± SD of the average deep foveal avascular zone (dFAZ) area was 1287.83 ± 220.22 µm2 pre-injection, 624.0 ± 65.35 post-injection with an improvement of 663.83 ± 281.0 (49.54%). Conclusion: Intravitreal injection of anti-VEGF was very effective in diabetic macular edema. Analysis of vascular density changes following anti-VEGF treatment for DME using Optical coherence tomography angiography (OCTA) was remarkably effective.
 

DOI

10.21608/scumj.2022.223250

Keywords

anti-VEGF, sFAZ, dFAZ, optical coherence tomography angiography (OCTA)

Authors

First Name

Ahmed

Last Name

Tawfek

MiddleName

Z.

Affiliation

Department of Ophthalmology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

ahmedzakaria@med.suez.edu.eg

City

Ismailia

Orcid

-

First Name

Mervat

Last Name

Elgharieb

MiddleName

E.

Affiliation

Department of Ophthalmology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

-

City

-

Orcid

-

First Name

Hussein

Last Name

Alnahass

MiddleName

S.

Affiliation

Department of Ophthalmology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

-

City

-

Orcid

-

First Name

Osama

Last Name

Alnahrawy

MiddleName

M.

Affiliation

Department of Ophthalmology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

-

City

-

Orcid

-

First Name

Amr

Last Name

Gab-Alla

MiddleName

A.

Affiliation

Department of Ophthalmology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

amrophth@hotmail.com

City

-

Orcid

-

Volume

25

Article Issue

2

Related Issue

31648

Issue Date

2022-07-01

Receive Date

2022-03-07

Publish Date

2022-07-01

Page Start

1

Page End

6

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 25_Issue 2_Pages 1-6.pdf

PDF . 270.8kB

Link

https://scumj.journals.ekb.eg/article_223250.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=223250

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Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023