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240848

The Clinical Outcome of Intravenous Single Bolus 0.5gm of Tranexamic Acid for Reducing Blood Loss Following an Elective Cesarean Delivery: A Randomized Controlled Trial

Article

Last updated: 04 Jan 2025

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Clinical Research (Medical)

Abstract

Objective: To assess the effectiveness and safety ofintravenous single bolus 0.5 gm Tranexamic acid ( TA ), compared with 1 gm TA and placebo in reducing blood loss during and after cesarean delivery in women who have at least one risk factor for postpartum hemorrhage(PPH). Subjects and Methods: A randomized clinical trial, at a tertiary University Hospital between November 1, 2018, and July 30, 2020, (: NCT03710330) was conducted on 360 pregnant women at term (37–40 weeks) gestation scheduled for elective cesarean delivery, who were assigned to either 0.5 gm,1 gm, or, placebo(saline). The main outcome measures were blood loss at and 6 hours after cesarean delivery, the need for any additional oxytocic drugs, and TA-related side effects. Results: The mean overall blood loss was (609.33 ± 211.5), intraoperative was (465.58 ± 191) and post-operative was (143.75 ± 33.33) in group 2 compared with (829.7 ± 293.3), (665.5 ± 272.2), (165.83 ± 36.59) in group 1 respectively and (751 ± 208.09), (587.75 ± 190.6), (164.08 ± 32.53) in group 3 respectively , so group 2 showed great significant reduction in overall estimated blood loss either intraoperative or post-operative compared with group 1 ,( p = 0.0001,0.0001,0.0001) and group 3, (p= 0.0001,0.0001,0.0001). Conclusion: Both 0.5 gm and 1 gm TA may be more effective than a placebo in reducing total blood loss during and after CD, but 1gm TA may be more effective than 0,5 gm TA in reducing blood loss during and after CD in women who have a minimum of one risk factor for postpartum hemorrhage, for instance, twin pregnancy, macrosomia, and history of PPH, etc.
 

DOI

10.21608/scumj.2022.240848

Keywords

Postpartum Hemorrhage, cesarean section, uterine atony

Authors

First Name

Nahla

Last Name

Shady

MiddleName

W.

Affiliation

Department of Obstetrics and Gynecology, Aswan Faculty of Medicine, Aswan University, Aswan, Egypt

Email

nahlagyn@yahoo.com

City

Aswan

Orcid

0000-0001-9023-8773

First Name

Hany

Last Name

Sallam

MiddleName

F.

Affiliation

Department of Obstetrics and Gynecology, Aswan Faculty of Medicine, Aswan University, Aswan, Egypt

Email

-

City

-

Orcid

-

Volume

25

Article Issue

1

Related Issue

28782

Issue Date

2022-03-01

Receive Date

2022-06-01

Publish Date

2022-03-01

Page Start

125

Page End

134

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 25_Issue 1_Pages 125-134.pdf

PDF . 395.5kB

Link

https://scumj.journals.ekb.eg/article_240848.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=240848

Order

13

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

The Clinical Outcome of Intravenous Single Bolus 0.5gm of Tranexamic Acid for Reducing Blood Loss Following an Elective Cesarean Delivery: A Randomized Controlled Trial

Details

Type

Article

Created At

22 Jan 2023