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237708

Vitamin D Deficiency in Patients with Systemic Lupus Erythematosus in Suez Canal University Hospital

Article

Last updated: 22 Jan 2023

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Tags

Clinical Research (Medical)

Abstract

Background: Systemic Lupus Erythematosus (SLE) is a multi-system chronic inflammatory autoimmune disease that compromises multiple organs and unpredictable course and prognosis. Vitamin D deficiency is implicated as a potential environmental factor triggering some autoimmune disorders, including SLE. Aim: To improve the management of SLE patients and reduce disabilities arising as a consequence of vitamin D deficiency. Objectives: Our objectives were to assess the prevalence of vitamin D deficiency in SLE patients and its relation to disease activity and renal involvement in those patients. Patients and Methods: We enrolled 72 SLE patients who fulfilled the revised classification criteria of the American College of Rheumatology whose ages were above or equal to 16 from both genders and who visited the outpatient clinic or were admitted to the inpatient departments of the Suez Canal university hospital. They were subjected to full medical history, examination, SLE disease activity index –SLEDAI- score assessment, and lab investigations (CBC, C3, C4, ESR, urine analysis, 24-hour urine protein, and vitamin D. Results: The mean of vitamin D level was nearly 19ng/ml ranging from 5 to 38ng/ml and 55.6% of the patients showed deficient level (< 20ng/ml). Our variables (disease activity, renal involvement, age, gender, BMI, and laboratory findings) were not correlated to vitamin D level except for disease duration which showed a strong negative relationship where vitamin D deficiency is remarkable when SLE duration exceeds 6 years (100%)"R = - 0.797and P >0.001". Conclusion: vitamin D deficiency is a common problem in SLE patients, also vitamin D deficiency was related to disease duration but not to disease activity or renal involvement.

DOI

10.21608/scumj.2022.237708

Keywords

hypovitaminosis D, Autoimmune Disorders, Proteinuria, Systemic lupus erythematosus, Vitamin D

Authors

First Name

Nada

Last Name

Motawei

MiddleName

A.

Affiliation

Internal Medicine Department, Suez Canal University Hospitals, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Email

-

City

-

Orcid

-

First Name

Gamal

Last Name

Tawfik

MiddleName

A.

Affiliation

Internal Medicine Department, Suez Canal University Hospitals, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Email

-

City

-

Orcid

-

First Name

Hanan

Last Name

Omar

MiddleName

H.

Affiliation

Clinical Pathology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Email

hananhassan1978@gmail.com

City

-

Orcid

-

First Name

Ayman

Last Name

Salem

MiddleName

-

Affiliation

Internal Medicine Department, Suez Canal University Hospitals, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Email

aymansalem2010@yahoo.com

City

Ismailia

Orcid

0000-0003-0234-8556

Volume

25

Article Issue

1

Related Issue

28782

Issue Date

2022-03-01

Receive Date

2022-05-17

Publish Date

2022-03-01

Page Start

114

Page End

124

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 25_Issue 1_Pages 114-124.pdf

PDF . 352.7kB

Link

https://scumj.journals.ekb.eg/article_237708.html

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https://scumj.journals.ekb.eg/service?article_code=237708

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Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

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Article

Created At

22 Jan 2023