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Association of Fibroblast Growth Factor-23 and Early Detection of Breast Arterial Calcification in Different Stages of Chronic Kidney Disease Patients

Article

Last updated: 04 Jan 2025

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Tags

Clinical Research (Medical)

Abstract

Background:Vascular calcification (VC) plays a major role in cardiovascular disease (CVD), which is one of the main causes of mortality in patients with chronic kidney disease (CKD). During the early stages of CKD, Fibroblast growth factor-23 (FGF-23) levels increase to keep serum phosphorus within the normal range. FGF23 may be associated with death and cardiovascular events in CKD patients. Aim:The study aimed at early detection of breast arterial calcification (BAC) and higher levels of FGF-23 as indicators of systemic VC in patients with different stages of CKD. Methodology: The patients were divided into 3 groups; representing stages 2, 3 & 4 of CKD women, and the 4th group was considered as a control group. The selected participants were subjected to history taking, mammogram to detect BAC and biochemical assessment of lipid profile, Serum creatinine, Mg, P, Ca, PTH and FGF23. Results: the presence of BAC in about 81.8% of stage 4 CKD patients compared with 50% in stage 3 CKD, also in the majority of stage 4 CKD patients had high FGF-23. Receiver operator characteristic (ROC) curve analysis showed serum FGF-23 as a potential predictor of BAC (AUC=0.874) in CKD patients at the cut-off point of 77.5ng/ml (sensitivity 78%, specificity 76%). Conclusion: Although it is difficult to determine the definite stage at which the risk of VC begins but, in our study, it began late in stage 2 CKD, gradually increased prevalence through stage 3, and became significantly higher in stage 4. FGF-23 could be a good predictor of BAC in CKD
 

DOI

10.21608/scumj.2022.210001

Keywords

vascular calcification, Fibroblast growth factor-23, Stages, Kidney disease

Authors

First Name

Basma

Last Name

Ibrahim

MiddleName

O

Affiliation

Department of Internal Medicine and Nephrology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Gamal

Last Name

Tawfik

MiddleName

A

Affiliation

Department of Internal Medicine and Nephrology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Housseini

Last Name

Ahmed

MiddleName

-

Affiliation

Department of Diagnostic Radiology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Hamdy

Last Name

Omar

MiddleName

H

Affiliation

Department of Internal Medicine and Nephrology, Faculty of Medicine, Suez Canal University, Egypt

Email

drhamdyomar@yahoo.com

City

-

Orcid

-

Volume

25

Article Issue

1

Related Issue

28782

Issue Date

2022-03-01

Receive Date

2021-12-20

Publish Date

2022-03-01

Page Start

80

Page End

91

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 25_Issue 1_Pages 80-91.pdf

PDF . 541.5kB

Link

https://scumj.journals.ekb.eg/article_210001.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=210001

Order

8

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Association of Fibroblast Growth Factor-23 and Early Detection of Breast Arterial Calcification in Different Stages of Chronic Kidney Disease Patients

Details

Type

Article

Created At

22 Jan 2023