Background: Obesity has become a major contributor to the global burden of chronic disease and disability. Studies have consistently found a modest association between depression and obesity. Meta-analysis of 17 community-based studies found that obese people were 1.18 times more likely to have depressive symptoms than those who were not obese. This relationship has been suggested to be dose dependent, with a higher body mass index (BMI) being linked to a greater likelihood of clinical depression. Aim: to estimate the frequency of major depressive disorders among obese adults patients. Patients and Methods: The present study was designed as descriptive analytical cross-sectional study that included 129 adult obese patients attending to Academic Port-Fouad Family Practice Center, Faculty of Medicine, Suez Canal University. Results: Mean age of the patients in different groups was comparable (p=0.52)., 53.5% of obese patients in our sample had no depression, whereas 41.9% had mild depressive symptoms and 4.7% are severely depressed. Frequency of eating dairy products was significantly different between depressed and non-depressed patients (p=0.027). Depressed patients significantly had a greater number of snakes (2.25 ± 1.83 times) than those with no depression (p=0.011). Depressed patients were significantly less satisfied with their body shape (p=0.008). Conclusion: Depression often accompanies obesity. Therefore, it is recommended that health professionals should always explore the presence of depression and suicidality in obese patients.