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192460

Insulin Resistance in Chronic Kidney Disease: Is There a Distinct Role of Vitamin D?

Article

Last updated: 22 Jan 2023

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Tags

Clinical Research (Medical)

Abstract

Background: Chronic kidney disease (CKD) is associated with significant morbidity and mortality. Many factors including inflammation, oxidative stress, and vitamin D deficiency contribute to insulin resistance (IR). Vitamin D requires attention because of the kidney's involvement in vitamin D metabolism, the high prevalence of vitamin D deficiency in CKD, and the effect of vitamin D that may cover multiple factors contributing to IR in CKD, as inflammation. Aim: To Identify the role of vitamin D deficiency in diabetic kidney disease (DKD) in type 2 diabetes mellitus (T2DM) patients. Patients and Methods: The study was performed as a cross-sectional study including 84 patients with T2DM admitted in Suez Canal University Hospitals. Results: In diabetics with normal kidney function 64.3% of patients had sufficient level of vitamin D, while 14.3% of patients had vitamin D deficiency. In diabetics with late nephropathy 46.4% of patients had vitamin D deficiency with significant relationship between the progress of DN and vitamin D level (p value ≤ 0.05). Conclusion:vitamin D deficiency is strongly associated with DN.
 

DOI

10.21608/scumj.2021.192460

Keywords

Chronic Kidney Disease, Insulin Resistance, Vitamin D

Authors

First Name

Heba

Last Name

Attea

MiddleName

A

Affiliation

Department of Internal Medicine, Faculty of Medicine, Suez Canal University, Egypt

Email

hebahakeem2009@yahoo.com

City

-

Orcid

-

First Name

Alaa El Din

Last Name

Abd El Hamid

MiddleName

S

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Mohammed

Last Name

Keshawy

MiddleName

M

Affiliation

Department of Internal Medicine, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Khedr

MiddleName

S

Affiliation

Department of Internal Medicine, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

Volume

24

Article Issue

2

Related Issue

27374

Issue Date

2021-10-01

Receive Date

2021-09-02

Publish Date

2021-10-01

Page Start

128

Page End

134

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 24_Issue 2_Pages 128-134.pdf

PDF . 394.6kB

Link

https://scumj.journals.ekb.eg/article_192460.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=192460

Order

5

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023