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192013

Insulin Resistance in Diabetic CKD: A Hospital-Based Study in Egypt

Article

Last updated: 22 Jan 2023

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-

Tags

Clinical Research (Medical)

Abstract

Background:The presence of insulin resistance (IR) and compensatory hyper-insulinemia is strongly associated with chronic kidney disease (CKD) stages and constellates with other abnormalities such as obesity, hypertension, and dyslipidemia. CKD is associated with significant morbidity and mortality. A variety of factors, including inflammation, oxidative stress and metabolic acidosis are associated with insulin resistance. Aim: To identify the relationship between insulin resistance and diabetic kidney disease (DKD). Patients and Methods: The study was performed as a cross-sectional study including 84 patients with type 2 diabetes mellitus admitted in Suez Canal University Hospitals. Results: In diabetics with normal kidney function 28.6% of had IR, while 78.6% of diabetic patients with late DKD had IR according to HOMA- IR with significant relationship between the progress of DKD and IR(p value ≤ 0.05).Conclusion: The presence of insulin resistance is strongly associated with DKD and its progress.

DOI

10.21608/scumj.2021.192013

Keywords

diabetes, dyslipidemia, kidney

Authors

First Name

Heba

Last Name

Attea

MiddleName

A

Affiliation

Department of Internal Medicine, Faculty of Medicine, Suez Canal University, Egypt

Email

hebahakeem2009@yahoo.com

City

-

Orcid

-

First Name

Alaa El Din

Last Name

Abd El Hamid

MiddleName

S

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Mohammed

Last Name

Keshawy

MiddleName

M

Affiliation

Department of Internal Medicine, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Khedr

MiddleName

S

Affiliation

Department of Internal Medicine, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

Volume

24

Article Issue

2

Related Issue

27374

Issue Date

2021-10-01

Receive Date

2021-08-30

Publish Date

2021-10-01

Page Start

104

Page End

108

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 24_Issue 2_Pages 104-108.pdf

PDF . 283.9kB

Link

https://scumj.journals.ekb.eg/article_192013.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=192013

Order

2

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

-

Details

Type

Article

Created At

22 Jan 2023