Specific Language Impairment Genes, Variants and Possible Gene-based Interventions - Egyptian Knowledge Bank

155491

Specific Language Impairment Genes, Variants and Possible Gene-based Interventions

Article

Last updated: 04 Jan 2025

Subjects

Abstract

Specific Language Impairment (SLI) is a communication neurodevelopmental disorder that manifests at the age of 3-5 years when a child lags his chronological speech development age by one year in the absence of medical, environmental, and psychological risk factors. SLI has been known to be highly heritable. Many studies have demonstrated different genes and loci to be implicated in SLI through linkage studies, the commonest of which were, FOXP2, ATP2C2, CMIP, CNTNAP2, DCDC2, KIAA0319, DYX1C1, SRPX2, NFXL1, ERC1, SETBP1, SEMA6D, AUTS2, and GRIN2A and B. In this review, we aim to present a comprehensive summary of the genes reported to be responsible or correlated to SLI and the common non-synonymous variants for each gene and their potential pathophysiological impact on normal speech development.

DOI

10.21608/scumj.2021.155491

Keywords

Specific language impairment (SLI), Genetic variants, Language genes

Authors

View Authors

First Name

Raghda

Last Name

Eldesouki

MiddleName

Affiliation

Genetics Unit, Department of Histology and Cell Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Email

rag.eldesouki@gmail.com

City

Orcid

Volume

Article Issue

Related Issue

22901

Issue Date

2021-03-01

Receive Date

2021-03-10

Publish Date

2021-03-01

Page Start

Page End

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 24_Issue 1_Pages 1-11.pdf

PDF . 320.9kB

Link

https://scumj.journals.ekb.eg/article_155491.html

Detail API

https://scumj.journals.ekb.eg/service?article_code=155491

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Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

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