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137210

Evaluation of Serum C24 Ceramide as a Predictor of Hepatic Decompensation in Patients with Liver Cirrhosis

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Last updated: 22 Jan 2023

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Clinical Research (Medical)

Abstract

Background: It was found that there is a significant progressive decrease in the serum level of C24 ceramide with increasing severity of cirrhosis. Our aim was to evaluate the efficacy of C24 Ceramide (C24Cer) as a predictor of decompensation in cirrhotic patients at Suez Canal University hospital, Ismailia, Egypt. Subjects and Methods: Patients with viral related liver cirrhosis were consecutively confronted in the outpatient and inpatient sections. They were classified according to Child-Pugh into A, B, C groups. A control group (13 individuals) was compared with each group. Clinical assessment and Liver profile were performed. The serum level of C24Cer was measured using 20μL extracted serum with methanol: chloroform: HCl (15:83:2), using liquid chromatography coupled to tandem mass spectrometry. Results: Patients with Child-A cirrhosis showed a significantly higher mean C24Cer level compared to Child-C patients (p <0.001). Pairwise comparisons showed a statistically significant stepwise decrease in the mean C24Cer level from control group to Child-A, B then C cirrhotic patients respectively (p-value: 0.029, <0.001, and <0.001). There was a highly significant negative correlation between C24Cer and each of total bilirubin, PT, ascites grade, hepatic encephalopathy grade, and Child score (p < 0.001 for each) as well as a highly significant positive correlation with albumin level (p < 0.001). Conclusion: a low serum C24Cer is associated with hepatic decompensation and is good with a sensitivity of 100% and a specificity of 73%. Further studies are needed to elucidate the real-life significance of C24Cer as a non-invasive mortality predictor in cirrhosis.
 

DOI

10.21608/scumj.2020.137210

Keywords

Liver cirrhosis, Child-Pugh classification, Ceramide 24

Authors

First Name

Fawzy

Last Name

Attia

MiddleName

-

Affiliation

Department of Internal Medicine, Faulty of Medicine, Suez Canal University, Ismailia, Egypt

Email

fawzyattia2007@yahoo.com

City

-

Orcid

-

First Name

Khalil

Last Name

Khalil

MiddleName

A.

Affiliation

Department of Internal Medicine, Faulty of Medicine, Suez Canal University, Ismailia, Egypt

Email

-

City

-

Orcid

-

First Name

Amira

Last Name

Abdelmonem

MiddleName

-

Affiliation

Department of Internal Medicine, Faulty of Medicine, Suez Canal University, Ismailia, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Abdel-Fattah

MiddleName

-

Affiliation

Department of Internal Medicine, Faulty of Medicine, Suez Canal University, Ismailia, Egypt

Email

-

City

-

Orcid

-

Volume

23

Article Issue

2

Related Issue

18442

Issue Date

2020-10-01

Receive Date

2021-01-08

Publish Date

2020-10-01

Page Start

214

Page End

220

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 23_Issue 2_Pages 214-220.pdf

PDF . 831.8kB

Link

https://scumj.journals.ekb.eg/article_137210.html

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https://scumj.journals.ekb.eg/service?article_code=137210

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12

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Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

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Article

Created At

22 Jan 2023